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NASA Pic of the Day

Latest version: (Mac release notes); (Win)
Download it free for    
Receive daily wallpaper updates featuring stunning high resolution images directly from the NASA Image of the Day gallery.

The daily image is saved to ~/Pictures/nasaiotd.jpg on Mac, and C:\Users\your_username\Pictures\NASA\PicOfTheDay on Windows.
Details about the image and the space and science information behind it are easily accessible through the tray icon.

The application will automatically update the wallpaper when it starts and daily at 12:00p EST (10:30a on Windows version) for as long as it is running and an internet connection is available. You can also manually check for updates.
Multiple monitors supported.

For more information read this blog announcement.